Currently, egg-white Lysozyme is allowed for the manufacture of cheese and wine as an anti-microbial stabilizer/additive in EU, USA, China and Japan, but residual amounts of egg-white lysozyme is considered sufficient to trigger allergic reactions in susceptible individuals. How to discover dosage-less and allergen-free of new source lysozyme are a big challenge.
The new generation of Lyosch™ G4 fermented lysozyme is produced by fermentation of bacterium Streptomyces sp. G4, it takes lysozyme to the new height against both Gram-positive and Gram-negative bacteria, only 2-5ppm can stop ‘late blowing’ in cheese without allergen risk.
In Cheese, Lysozyme is considered as generally recognized as safe (GRAS) by the U.S. FDA and approved as a preservative (E1105) under the European Additives Directive to prevent late blowing in ripened cheese. Lysozyme is also approved for use in cheese in Australia, Canada, China, Japan and South Korea. In wine, OIV has approved Lysozyme as active ingredient to the level of 500 ppm (50 grams per hectoliter). The European Union has approved the use of Lysozyme as of October 26, 2001. The use of Lysoch G4 in food and beverage regulations should always be consulted concerning the status of this product with the local authorities.